Targeted drug delivery system for doxorubicin based on a specific peptide and phospholipid nanoparticles

• DOI: 10.18097/pbmc20206606464
• Publication Date: 2020-12-29T06:17:32Z
• Authors: L.V. Kostryukova; Y.A. Tereshkina; E.I. Korotkevich; V.N. Prozorovsky; T.I. Torkhovskaya; G.E. Morozevich; I.Y. Toropygin; M.A. Konstantinov; E.G. Tikhonova
• Keywords: Targeted drug delivery

Doxorubicin is one of the widely known and frequently used chemotherapy drugs for treatment various types cancer, use which difficult due to its high cardiotoxicity. Targeted drug delivery systems are being developed reduce side effects. One promising components as vector molecules (ligands) NGR-containing peptides that affinity CD13 receptor, expressed on surface many tumor cells blood vessels. Previously, a method was preparing composition doxorubicin embedded in phospholipid nanoparticles with targeted fragment form an ultrafine emulsion. The resulting characterized by small particle size (less than 40 nm) degree incorporation (about 93%) into transport nanoparticles. When assessing penetrating ability binding fibrosarcoma (HT-1080), it shown when added cells, level almost 2 times higher liposomal doxorubicin, i.e. system peptide penetrated cell better. At same time, control line breast adenocarcinoma (MCF-7), do not express receptor surface, there significant difference cells. data obtained allow us draw preliminary conclusions about prospects using conjugate containing NGR motif further need comprehensive study.