Onset of Nut Allergy in a Pediatric Cohort: Clinical and Molecular Patterns in the AFRUSEN Study

• DOI: 10.18176/jiaci.0696
• Publication Date: 2021-04-22T11:42:09Z
• Authors: MD Ibáñez-Sandin; P Rodríguez del Río; MI Alvarado; BE García; T Garriga-Baraut; M Reche Frutos; C Escudero; A Ramirez Jiménez; L Vila; EM Lasa; C Blasco; E Marchán-Martin; A Martorell; S Sanchez-García; M Rodríguez-Álvarez; S Infante; V Rodríguez Vazquez; JM Olaguibel; M Labrador-Horrillo; T Carrillo
• Keywords: Peanut Allergy; Brazil nut

Nut allergy is a growing problem, yet little known about its onset in children. Objective: To characterize the of nut children southern Europe.The study population comprised consecutive patients up to 14 years age who visited departments with an initial allergic reaction peanut, tree nut, or seed. The work-up included clinical history, food challenge, skin prick testing, determination whole-extract sIgE, and ImmunoCAP ISAC-112 assay.Of 271 included, 260 were first diagnosed at mean 6.5 (SD) 11.8 (21.2) months after index reaction. most common culprit nuts walnut (36.5%), peanut (28.5%), cashew (10.4%), hazelnut (8.5%), pistachio (5.4%), almond (5%). Onset was more frequent ≤6 those aged >6 (P=.032). In 65% cases, occurred time patient consumed 35% reactions anaphylactic. Overall, polysensitization detected by testing 64.9% patients, although this rate lower among walnut-allergic (54.7%) peanut-allergic (54.1%) (P<.0001). Sensitization 2S albumins predominant (75%), especially Jug r 1 (52.8%), whereas sensitization lipid transfer proteins less relevant (37%).In we assessed, around 6 age, slightly later than that reported English-speaking countries. Walnut main trigger, followed peanut. albumin storage proteins, 1, allergens. This will help guide management may contribute preventive strategies pediatric allergy.