Dynamic changes of spontaneous brain activity in patients after LASIK: a resting-state fMRI study

• DOI: 10.18240/ijo.2025.03.16
• Publication Date: 2025-02-20T07:52:31Z
• Authors: Hui Zhang; Jin-Yu Hu; ; Zhen-Zhe Liu; ; Lei Zhong; ; Liang-Qi He; ; Cheng Chen; ; Xiao-Yu Wang; ; Hong Wei; ; Yan-Mei Zeng; ; Qian Ling; ; Xu Chen; ; Yi-Xin Wang; ; Yi Shao
• Keywords: LASIK; Precentral gyrus

AIM: To investigate changes in local brain activity after laser assisted situ keratomileusis (LASIK) myopia patients, and further explore whether post-LASIK (POL) patients healthy controls (HCs) can be distinguished by differences dynamic amplitude of low-frequency fluctuations (dALFF) specific regions. METHODS: The resting-state functional magnetic resonance imaging (rs-fMRI) data were collected from 15 myopic who underwent LASIK matched controls. This method was selected to calculate the corresponding dALFF values each participant, compare between groups determine distinguishes reliably HCs using linear support vector machine (SVM) permutation test (5000 repetitions). RESULTS: lower POL than at right precentral gyrus insula. Classification accuracy SVM 89.1% (P<0.001). CONCLUSION: spontaneous neurons insula change significantly LASIK. correctly classify based on differences.