First report of chronic invasive fungal rhinosinusitis in a patient with ovarian cancer caused by Didymella pedeiae and successful treatment with voriconazole: A case report

• DOI: 10.18502/cmm.7.1.6244
• Publication Date: 2021-07-07T11:56:17Z
• Authors: Omid Raiesi; Seyed Jamal Hashemi; Muhammad Ibrahim ...; Pegah Ardi; Mojtaba Mohammadi...; Vahid Raissi; Sina Shamsaei; Zeinab Borjian Bo...
• Keywords: Ethmoid sinus; Frontal sinus

Didymella pedeiae is a dematiaceous fungus that belongs to the Coelomycetes class. While species within this class are known cause human infection, D. had previously only been as phytopathogens and never isolated from sample.A 51-year-old Iranian female patient with ovarian cancer was admitted unilateral lesions in paranasal sinuses five-month history of nasal obstruction, headache, postnasal drainage, swelling on left side face, orbital pain. Paranasal sinus computerized tomography scan revealed soft tissue mass filled cavity, ethmoid, sphenoid, frontal more involvement maxillary ethmoid sinuses. Antifungal treatment simultaneously initiated itraconazole+prednisolone 15 mg/day, levofloxacin. Due poor clinical response, IV voriconazole amphotericin B were added well. The recovered completely after 10 weeks therapy.Here, we report first case infection cancer.