Does Erythropoietin Improve Consciousness in Severe Hypoxic Encephalopathy?

• DOI: 10.18502/jimc.v5i2.10471
• Publication Date: 2022-09-03T09:40:52Z
• Authors: Hamidreza Azizi F...; Noormohammad Arefian; Shayesteh Khorasa...; Faranak Behnaz; Firoozeh Madadi
• Keywords: Coma (optics); Hypoxia; Hypoxic-Ischemic Encephalopathy

Background: Although the effect of Erythropoietin (EPO) in neonatal and animal model hypoxic ischemic encephalopathy has been previously reported, its on comatose patients adult human yet to be investigated. Methods: This study was designed find intravenous administration EPO recovery from coma with Cardiac Arrest (CA)-induced encephalopathy. randomized controlled trial performed 60 CA who survived Cardiopulmonary Resuscitation (CPR) April 2011 Nov 2020. The were randomly divided into two equal groups including control, received normal saline, groups, demographic data recorded. EEG Glasgow Coma Scale (GCS) recorded hours 6, 12, 24, 48 post-success CPR interpreted by an expert neurologist. Magnetic Resonance Imaging (MRI) done at 24 72 hr post-CPR radiologist. All checked twice daily cardiologist. Results: included this study. There no significant difference between terms data. also GCS all interval times. No observed both respect frequency pre-existing metabolic acid-base disorders. Conclusion: CA-induced