Glycation of macrophages induces expression of pro-inflammatory cytokines and reduces phagocytic efficiency

• DOI: 10.18632/aging.102123
• Publication Date: 2019-07-29T18:48:27Z
• Authors: Veronika Bezold; Philip Rosenstock; Jonas Scheffler; Henriette Geyer; Rüdiger Horstkorte; Kaya Bork
• Keywords: RAGE; Advanced glycation end-product

Glycation and the accumulation of advanced glycation end products (AGEs) are known to occur during normal aging but also in progression several diseases, such as diabetes. Diabetes type II both lead impaired wound healing. It has been demonstrated that macrophages play an important role healing, however, underlying causes remain unknown. Elevated blood glucose levels well elevated methylglyoxal (MGO) diabetic patients result increase AGEs. We used MGO investigate influence AGEs on macrophages. could show glycation, not treatment with AGE-modified serum proteins, increased expression pro-inflammatory cytokines interleukin 1β (IL-1β) IL-8 affected IL-10 TNF-α expression, resulting inflammation. At same time, reduced phagocytic efficiency led clearance rates invading microbes cellular debris. Our data suggest contributes changes macrophage activity cytokine therefore support understanding disturbed healing