Evidence of a pan-tissue decline in stemness during human aging

• DOI: 10.18632/aging.205717
• Publication Date: 2024-04-04T18:39:56Z
• Authors: Gabriel Arantes d...; Gustavo Daniel Ve...; João Pedro de Mag...
• Keywords: Senescence

Despite their biological importance, the role of stem cells in human aging remains to be elucidated. In this work, we applied a machine learning methodology GTEx transcriptome data and assigned stemness scores 17,382 healthy samples from 30 tissues aged between 20 79 years. We found that ~60% studied exhibit significant negative correlation subject's age score. The only exception was uterus, where observed an increased with age. Moreover, is positively correlated cell proliferation negatively cellular senescence. Finally, also trend hematopoietic derived older individuals might have higher scores. conclusion, show evidence pan-tissue loss during aging, which adds weight idea deterioration may contribute aging.