The elevated preoperative fasting blood glucose predicts a poor prognosis in patients with esophageal squamous cell carcinoma: The Fujian prospective investigation of cancer (FIESTA) study

• DOI: 10.18632/oncotarget.11247
• Publication Date: 2016-08-12T21:04:36Z
• Authors: Dan Hu; Feng Peng; Xiandong Lin; Gang Chen; Binying Liang; Chao Li; Hejun Zhang; Xuehong Liao; Jinxiu Lin; Xiongwei Zheng; Wenquan Niu
• Keywords: Adult; Blood Glucose; Male; Esophageal Neoplasms; Kaplan-Meier Estimate; Middle Aged; Prognosis; 3. Good health; Cohort Studies; Diabetes Complications; 03 medical and health sciences; 0302 clinical medicine; Carcinoma, Squamous Cell; Diabetes Mellitus; Humans; Female; Esophageal Squamous Cell Carcinoma; Research Paper; Aged; Follow-Up Studies

// Dan Hu 1, * , Feng Peng 2, Xiandong Lin Gang Chen 1 Binying Liang 3 Chao Li Hejun Zhang Xuehong Liao Jinxiu 2 Xiongwei Zheng Wenquan Niu 4 Department of Pathology, Fujian Provincial Cancer Hospital, The Affiliated Hospital Medical University, Fuzhou, Fujian, China Cardiology, First Medical-Record Department, State Key Laboratory Genomics, Rui Jin Shanghai Jiao Tong University School Medicine, Shanghai, Shared first authors Correspondence to: Peng, email: [e-mail] Zheng, [e-mail] Niu, [e-mail] Keywords: fasting blood glucose, esophageal squamous cell carcinoma, prognosis, mortality, FIESTA study Received: May 09, 2016 Accepted: July 28, Published: August 12, ABSTRACT Diabetes as a latent risk factor for cancer has been extensively investigated, while its postoperative prognosis is rarely reported. We therefore sought to assess whether the elevated glucose before surgery was associated with poor survival in patients by eliciting subset data from ongoing F ujian prospect i ve inv est igation c ncer (FIESTA) study. Over 15-year follow-up, 2535 receiving three-field lymphadenectomy were assessable. Only carcinoma (ESCC) (n=2396) analyzed due lower prevalence other histological types. In ESCC patients, follow-up duration ranged 0.5 180 months (median 38.2 months). median time (MST) remarkably shorter males than females (80.7 vs. 180+ months, Log-rank test: P<0.001). males, worse diabetes those without (MST: 27.9 111.1 females, survivor improved 71.5 months), but still overall multivariate hazard ratio per unit increment 1.11 (95% confidence interval or CI: 1.09-1.14, P<0.001) and 1.08 1.03-1.13, P=0.002) respectively. Further tree analysis consolidated discrimination ability patients. Taken together, our findings convincingly demonstrated that preoperative can predict especially males.