Immunohistochemical correlates of TP53 somatic mutations in cancer

• DOI: 10.18632/oncotarget.11912
• Publication Date: 2016-09-09T03:33:08Z
• Authors: Balázs Murnyák; Tibor Hortobágyi
• Keywords: Dominance (genetics)

// Balázs Murnyák 1 and Tibor Hortobágyi Division of Neuropathology, Institute Pathology, Faculty Medicine, University Debrecen, Hungary Correspondence to: Hortobágyi, email: Keywords : IARC TP53 Database, immunohistochemistry, mutations, cancer, p53 Received June 17, 2016 Accepted September 01, Published 08, Abstract Despite controversy on the correlation between accumulation mutational status, i mmunohistochemical (IHC) detection overexpressed protein has long been used as a surrogate method for mutation analysis. The aim our study was to characterise IHC expression features somatic mutations define their occurrence in human cancers. A large-scale database analysis conducted Database (R17); 7878 with were retrieved representing 60 distinct tumour sites. majority alterations immunopositive ( p <0.001). Sex known 4897 showing female dominance (57.2%) females carrying negative significantly younger. divided into three groups according frequency positivity. Each group had dominance. Among groups, significant correlations observed age at diagnosis breast, bladder, liver, haematopoietic system head & neck An increased likelihood false associated rare nonsense certain Our demonstrates that immunopositivity largely correlates status but is absent types.Besides, describing complex results reveal some caveats diagnostic practice.