High expression of the long non-coding RNA HEIRCC promotes Renal Cell Carcinoma metastasis by inducing epithelial-mesenchymal transition

• DOI: 10.18632/oncotarget.14149
• Publication Date: 2016-12-28T01:36:04Z
• Authors: Jing Xiong; Ying Liu; Shengjun Luo; Li Jiang; Yang Zeng; Zhixiong Chen; Xiaobo Shi; Bufan Lv; Wei Tang
• Keywords: Male; Epithelial-Mesenchymal Transition; Apoptosis; 03 medical and health sciences; 0302 clinical medicine; Cell Movement; Cell Line, Tumor; Biomarkers, Tumor; Humans; Neoplasm Invasiveness; Carcinoma, Renal Cell; Cell Proliferation; Oligonucleotide Array Sequence Analysis; Gene Expression Profiling; Cell Differentiation; Middle Aged; Kidney Neoplasms; 3. Good health; Gene Expression Regulation, Neoplastic; Lymphatic Metastasis; Female; RNA Interference; RNA, Long Noncoding; Research Paper

Increasing evidence indicates that long non-coding RNAs (lncRNAs) have been associated with cancer development. However, the contributions of lncRNAs to renal cell carcinoma (RCC) remain poorly characterized. Here, we identified a novel lncRNA, termed HEIRCC, which was up-regulated in RCC tissues through lncRNA microarray analysis and subsequent validation 60 clinical specimens lines. The high expression HEIRCC is closely pathology features such as larger tumor size, poor differentiation, lymphatic metastasis. In vitro assays revealed knockdown could inhibit proliferation, trigger late apoptosis, suppress migration invasion. We further demonstrated depletion reduce epithelial mesenchymal transition (EMT) program by regulating levels EMT-associated markers cells. Thus, might be act an important regulator EMT progression therapeutic target for advanced therapy.