Identification of long non-coding RNAs GAS5, linc0597 and lnc-DC in plasma as novel biomarkers for systemic lupus erythematosus

• DOI: 10.18632/oncotarget.15569
• Publication Date: 2017-02-22T16:33:37Z
• Authors: Guo-Cui Wu; Jun Li; Rui-Xue Leng; Xiang-Pei Li; Xiao-Mei Li; De-Guang Wang; Hai-Feng Pan; Dong-Qing Ye
• Keywords: GAS5; Nephritis; Plasma levels

Despite increasing evidence that long non-coding RNAs (lncRNAs) widely take part in human diseases, the role of lncRNAs systemic lupus erythematosus (SLE) is largely unknown. In this study, we performed a two-stage study to explore plasma levels five (GAS5, linc0949, linc0597, HOTAIRM1 and lnc-DC) their potential as SLE biomarkers. Compared with healthy controls, GAS5 lnc-DC were significantly decreased (P < 0.001 P = 0.002, respectively) while linc0597 overexpressed patients 0.001). When divided into without nephritis (LN), higher LN compared 0.018), but no significant difference found between nephritis; linc0949 level showed all comparisons. Further evaluation on biomarkers GAS5, may specifically identify SLE, combination provided better diagnostic accuracy; discriminate from nephritis. summary, could be for SLE.