Circulating pre-treatment Epstein-Barr virus DNA as prognostic factor in locally-advanced nasopharyngeal cancer in a non-endemic area

• DOI: 10.18632/oncotarget.17822
• Publication Date: 2017-05-11T21:17:21Z
• Authors: Salvatore Alfieri; Nicola Alessandro...; Sara Marceglia; Irene Lasorsa; Carlo Resteghini; Francesca Taverna; Arabella Mazzocchi; Ester Orlandi; Marco Guzzo; Roberto Bianchi; Diana Fanti; Laura Pala; Sara Racca; Roee Dvir; Pasquale Quattrone; Annunziata Gloghini; Chiara Costanza V...; Roberta Granata; Cristiana Bergamini; Laura Locati; Lisa Licitra; Paolo Bossi
• Keywords: Nasopharyngeal cancer; Cancer Treatment

// Salvatore Alfieri 1 , Nicola Alessandro Iacovelli 2 Sara Marceglia 3 Irene Lasorsa Carlo Resteghini Francesca Taverna 4 Arabella Mazzocchi Ester Orlandi Marco Guzzo 5 Roberto Bianchi Diana Fanti 6 Laura Pala 7 Racca 8 Roee Dvir Pasquale Quattrone 9 Annunziata Gloghini Chiara Costanza Volpi Roberta Granata Cristiana Bergamini Locati Lisa Licitra 1, 10 and Paolo Bossi Department of Medical Oncology 3, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy Radiation Oncology, Engineering Architecture, University Trieste, Laboratory Immunohematology & Transfusion Medicine, Head Neck Surgery, Clinical Chemistry Microbiology, ASST Grande Ospedale Metropolitano Niguarda, Melanoma Sarcoma, Europeo di Oncologia, Microbiology Virology, San Raffaele Hospital, Pathology, Correspondence to: Alfieri, email: [e-mail] Keywords: nasopharyngeal cancer, Epstein-Barr virus, prognosis, head neck non endemic Received: February 06, 2017      Accepted: April 12, Published: May 11, 2017 ABSTRACT The prognostic value pre-treatment Virus (EBV) DNA viral load for non-endemic, locally-advanced, EBV-related cancer (NPC) patients is yet to be defined. All with EBV encoded RNA (EBER)-positive NPC treated at our Institution from 2005 2014 chemotherapy (CT) concurrent radiation (RT) +/- induction (ICT) were retrospectively reviewed. Pre-treatment baseline plasma (b-EBV DNA) was detected quantified by PCR. Median b-EBV correlated potential influencing factors univariate analysis. Significant variables then extrapolated included in a multivariate linear regression model. same variables, including DNA, Disease Free Survival (DFS) Overall (OS) A total 130 locally-advanced EBER positive evaluated. Overall, 103 (79.2%). 554 copies/mL (range 50–151075), positively T stage (p=0.002), N3a-b vs N0-1-2 (p=0.048), type treatment (ICT followed CTRT, p=0.006) locoregional and/or distant disease recurrence (p=0.034). In the overall population, DFS OS significantly longer negative than subjects Negative can considered as biomarker non-endemic areas. This finding needs confirmation larger prospective series, standardized inter-laboratory harmonized method quantification.