Clinical roles of the aberrantly expressed lncRNAs in lung squamous cell carcinoma: a study based on RNA-sequencing and microarray data mining

• DOI: 10.18632/oncotarget.18058
• Publication Date: 2017-05-22T13:18:25Z
• Authors: Wen-Jie Chen; Rui-Xue Tang; Rong-Quan He; Dong-Yao Li; Liang Liang; Jiang-Hui Zeng; Xiao-Hua Hu; Jie Ma; Shi-Kang Li; Gang Chen
• Keywords: 0301 basic medicine; 03 medical and health sciences; Research Paper; 3. Good health

Lung squamous cell carcinoma (LUSC) accounts for a significant proportion of lung cancer and there have been few therapeutic alternatives recurrent LUSC due to the lack specific driver molecules. To investigate prospective role lncRNAs in tumorigenesis progression LUSC, aberrantly expressed were calculated based on The Cancer Genome Atlas RNA-seq data. Of 7589 with 504 cases, 884 identified as being (|log2 fold change| >2 adjusted P<0.05) by DESeq R. top 10 highest diagnostic value SFTA1P,LINC00968, LINC00961, LINC01572,RP1-78O14.1, FENDRR, LINC01314,LINC01272, GATA6-AS1, MIR3945HG. In addition roles carcinogenesis several also played vital parts survival LUSC. SFTA1P, LINC01272, GATA6-AS1 MIR3945HG closely related time Furthermore, LINC01572 LINC01314 could distinguish at early stage from that advanced stage. molecular assessment key showed certain series genes be involved regulation network. OncoPrint cBioPortal indicated 14% (69/501) cases genetic alterations obtained, including amplification, deep deletion mRNA upregulation. More interestingly, had poorer compared those without alterations. Overall, study propounds potentiality interpreting pathogenesis development lncRNAs, provides novel platform searching more capable biomarkers