Characterization of infiltrating lymphocytes in human benign and malignant prostate tissue

• DOI: 10.18632/oncotarget.19528
• Publication Date: 2017-07-24T21:28:01Z
• Authors: Emelie Rådestad; Lars Egevad; Carl Jorns; Jonas Mattsson; Berit Sundberg; Silvia Nava; Bo-Göran Ericzon; Lars Henningsohn; Victor Levitsky; Michael Uhlin
• Keywords: Immune checkpoint

Immune checkpoint blockade has shown promising results in numerous cancer types. However, prostate (PC), absent or limited responses have been reported. To investigate further, we compared the phenotype of infiltrating T-cells isolated from tissue patients with PC (n = 5), benign prostatic hyperplasia (BPH) 27), BPH concurrent 4) and controls 7). The majority were CD8+ had a CCR7-CD45RO+ effector memory phenotype. yield lesions was on average 20-fold higher than that obtained control prostates. Furthermore, there differences between conditions regarding percentage expressing several activation markers co-inhibitory receptors. In conclusion, many prostate-infiltrating express receptors PD-1 LAG-3, regardless condition. Despite observed increase counts percentages PD-1+ PC, concomitant demonstration high prostates suggests may play role controlling homeostasis rather contributing to PC-associated immune-suppression. Thus, not be good candidate for these data are relevant evaluation clinical trials designing future immunotherapeutic approaches PC.