MicroRNA-873 inhibits colorectal cancer metastasis by targeting ELK1 and STRN4

• DOI: 10.18632/oncotarget.24115
• Publication Date: 2018-01-10T11:24:09Z
• Authors: Chuannan Fan; Biyu Lin; Zhengjie Huang; Dan Cui; Minyi Zhu; Zhenling Ma; Yunda Zhang; Fan Liu; Yingfu Liu
• Keywords: 0301 basic medicine; 03 medical and health sciences; Clinical Research Paper; 3. Good health

MicroRNAs (miRNAs) are a group of small non-coding RNAs that directly bind to the 3'-untranslated-region (3'UTR) mRNA, thereby blocking gene expression post-transcriptionally. Accumulating evidence prove microRNA-873 (miR-873) functions as promoter or suppressor in various cancers, while whether it affects progression colorectal cancer (CRC) is yet unknown. Here we found miR-873 was downregulated human CRC clinical samples, mouse specimens and cell lines with high metastatic potential. We also demonstrated low closely associated poor prognosis CRC. Overexpressing suppressed proliferation metastasis cells both vitro vivo, inhibiting promoted proliferation, migration invasion vitro. Moreover, exerted its function by perturbing ERK-CyclinD1 pathway epithelial-mesenchymal transition (EMT) process. Furthermore, revealed acted tumor-suppressive microRNA binding 3'UTRs ELK1 STRN4 their expression. Our study uncovered an inhibitory role might provide promising marker for diagnosis prognosis.