Prevalence of non-syndromic orofacial clefts: based on 15,094,978 Chinese perinatal infants

• DOI: 10.18632/oncotarget.24238
• Publication Date: 2018-01-15T07:12:13Z
• Authors: Dazhi Fan; Shuzhen Wu; Li Liu; Qing Xia; Guo Tian; Wen Wang; Shaoxin Ye; Lijuan Wang; Jiaming Rao; Xiao Yang; Zhen Yu; Lihong Xin; Song Li; Zhenghua Duan; Tianchen Zhang; Song Wu; Xiaoling Guo; Zhengping Liu
• Keywords: Biostatistics

// Dazhi Fan 1, 2 , Shuzhen Wu Li Liu 3, 5 Qing Xia 6 Guo Tian Wen Wang Shaoxin Ye Lijuan Jiaming Rao 7 Xiao Yang 8 Zhen Yu 9 Lihong Xin 10 Song 11 Zhenghua Duan 12 Tianchen Zhang 13 4 Xiaoling and Zhengping 1 Foshan Institute of Fetal Medicine, Southern Medical University Affiliated Maternal Child Health Hospital Foshan, Guangdong, 528000, China Department Obstetrics, 3 Epidemiology Biostatistics, School Public Health, Anhui University, Hefei, Anhui, 230032, Integrated Traditional Western Chinese 230038, Library, The First Hospital, College Zhejiang Hangzhou, Zhejiang, 310003, Menzies for Research, Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia Epidemiology, Jinan Guangzhou, 510632, Changzhou Center Disease Control Prevention, Changzhou, Jiangsu, 213003, Maternal, Adolescent Neurology, Second Soochow Suzhou, Jiangsu 215004, Chaohu Chaohu, 238000, Chengdu Chengdu, Sichuan, 610041, Communicable Diseases Control, Jiangxi Provincial Nanchang 330000, Jiangxi, Correspondence to: Liu, email: [e-mail] Guo, [e-mail] Keywords: non-syndromic orofacial clefts; perinatal infants; prevalence; meta-analysis; Received: June 27, 2017      Accepted: December 05, Published: January 13, 2018 ABSTRACT Non-syndromic clefts (NSOFC), which include cleft lip palate (CLP), only (CLO), (CPO), contains a range disorders affecting the lips oral cavity. No systematic review meta-analysis has been carried out to synthesize prevalence NSOFC in infants. We aimed quantify understand variation national regional levels. Four English databases four were searched using comprehensive search strategy from inception April 2017. random effect model was used this meta-analysis. To determine sources heterogeneity, subgroup analyses meta-regression conducted based on different categories. protocol pre-registered PROSPERO, number CRD42017062293. 110 studies, including 15,094,978 infants, eligible inclusion. pooled rate 1.67‰ (95% CI 1.53–1.82), varying with provinces. estimate 0.56‰ (0.50–0.63) CLO, 0.82‰ (0.73–0.90) CLP, 0.27‰ (0.24–0.30) CPO. Significant associations found between overall estimates survey year study region. severe results will serve as baseline future assessment effectiveness control, also support inform health policy planning helping debates.