BTG1 expression correlates with pathogenesis, aggressive behaviors and prognosis of gastric cancer: a potential target for gene therapy

• DOI: 10.18632/oncotarget.4081
• Publication Date: 2015-09-15T04:50:54Z
• Authors: Hua-chuan Zheng; Jing Li; Dao-fu Shen; Xue-feng Yang; Shuang Zhao; Ya-zhou Wu; Yasuo Takano; Hong-zhi Sun; Rong-jian Su; Jun-sheng Luo; Wen-feng Gou
• Keywords: Pathogenesis

// Hua-chuan Zheng 1 , Jing Li 2 Dao-fu Shen Xue-feng Yang Shuang Zhao Ya-zhou Wu Yasuo Takano 3 Hong-zhi Sun Rong-jian Su 4 Jun-sheng Luo Wen-feng Gou Cancer Research Center, Key Laboratory of Brain and Spinal Cord Injury Liaoning Province, Animal The First Affiliated Hospital Medical University, Jinzhou, China Department Gastroenterology, School Health Science, Tokyo University Technology, Ohta-ku, Tokyo, Japan Experimental Correspondence to: Gou, e-mail: [e-mail] Keywords: gastric cancer, BTG1, pathobiological behaviors, carcinogenesis, gene therapy Received: March 11, 2015 Accepted: May 23, Published: June 05, ABSTRACT Here, we found that BTG1 overexpression inhibited proliferation, migration invasion, induced G /M arrest, differentiation, senescence apoptosis in BGC-823 MKN28 cells ( p < 0.05). transfectants showed a higher mRNA expression Cyclin D1 Bax but lower cdc2, p21, mTOR MMP-9 than the control mock After treated with cisplatin, MG132, paclitaxel SAHA, both viability time- dose-dependent manners 0.05) hypoexpression chemoresistance-related genes slug CD147 GRP78 GRP94 FBXW7 TOP1 TOP2 GST-π ). was restored after 5-aza-2′-deoxycytidine treatment cancer cells. statistically non-neoplastic mucosa metastatic lymph node positively correlated depth lymphatic venous metastasis, TNM staging worse prognosis diffuse-type carcinoma less intestinal- mixed-type ones suppressed tumor growth lung metastasis by inhibiting enhancing autophagy xenograft models. It suggested down-regulated might promote carcinogenesis partially due to its promoter methylation. reverse aggressive phenotypes be employed as potential target for cancer.