Oxidized low-density lipoprotein is a common risk factor for cardiovascular diseases and gastroenterological cancers via epigenomical regulation of microRNA-210

• DOI: 10.18632/oncotarget.4152
• Publication Date: 2015-09-16T17:47:25Z
• Authors: Ku-Chung Chen; Yi-Chu Liao; Jaw-Yuan Wang; Ying-Chu Lin; Chung-Ho Chen; Suh-Hang Hank Juo
• Keywords: Carotid Artery Diseases; Male; 0301 basic medicine; Chromatin Immunoprecipitation; Mice, Inbred BALB C; Binding Sites; Computational Biology; Mice, Nude; DNA Methylation; Epigenesis, Genetic; 3. Good health; Lipoproteins, LDL; Mice; 03 medical and health sciences; Cardiovascular Diseases; Cell Movement; Human Umbilical Vein Endothelial Cells; Animals; Humans; CpG Islands; DNA (Cytosine-5-)-Methyltransferases; Hypoxia; Aorta

Hyperlipidemia, including the oxidized low-density lipoprotein (oxLDL) accumulation, is a risk and highly associated with development of cancers cardiovascular diseases. microRNA-210 (miR-210), hypoxia-responsive microRNA regulated by HIF-1α, has been implicated in cancer disease formation. Furthermore, Bioinformatics analysis revealed that promoter miR-210 gene contains CpG-rich regions. It unclear whether expression could be epigenetically these progresses. The study aimed to explore relationships between lipid context gastrointestinal cancer. We demonstrated oxLDL can decrease methylation up-regulate miR-210. HIF-1α bind promoter, but this binding site blocked methylation. showed subjects carotid atherosclerosis, stroke patients had hypomethylation especially site. directly inhibit sprouty-related EVH1 domain 2 (SPRED2) expressions, SPRED2 reduces cell migration via ERK/c-Fos/MMPs pathways. Increased reduced levels were found aorta mice under high-fat diet tumor tissues, which implied an underlying mechanism explain as common factor for