Low DICER1 expression is associated with poor clinical outcome in adrenocortical carcinoma

• DOI: 10.18632/oncotarget.4261
• Publication Date: 2015-09-15T04:47:30Z
• Authors: Gabriela Resende ...; Tamaya C. Ribeiro; Andre M. Faria; Beatriz M.P. Mariani; Antonio M. Lerario; Maria Claudia N. ...; Iberê C. Soares; Alda Wakamatsu; Venancio A.F. Alves; Berenice B. Mendonca; Maria Candida B.V...; Ana Claudia Latro...; Madson Q. Almeida
• Keywords: Adenoma; Adult; Male; Ribonuclease III; 0303 health sciences; Adolescent; RNA-Binding Proteins; Middle Aged; Survival Analysis; Adrenal Cortex Neoplasms; Disease-Free Survival; DEAD-box RNA Helicases; Young Adult; 03 medical and health sciences; Treatment Outcome; Adrenocortical Carcinoma; Disease Progression; Humans; Female; Aged

// Gabriela Resende Vieira de Sousa 1 , Tamaya C. Ribeiro Andre M. Faria Beatriz M.P. Mariani Antonio Lerario 1, 2 Maria Claudia N. Zerbini 3 Iberê Soares Alda Wakamatsu Venancio A.F. Alves 2, Berenice B. Mendonca Candida B.V. Fragoso Ana Latronico Madson Q. Almeida Unidade Suprarrenal, Endocrinologia do Desenvolvimento, Laboratório Hormônios e Genética Molecular LIM42, Divisão Metabologia, Hospital das Clínicas, Faculdade Medicina da Universidade São Paulo, SP, Brazil Instituto Câncer Estado Patologia Hepática LIM14, Anatomia Patológica, Correspondence to: Almeida, e-mail: [e-mail] Keywords: DICER1, TARBP2, miRNA, adrenocortical carcinoma, recurrence Received: April 25, 2015 Accepted: May 30, Published: June 11, ABSTRACT Low DICER1 expression was associated with poor outcome in several cancers. Recently, hot-spot mutations were found ovarian tumors, and TARBP2 truncating tumor cell lines microsatellite instability. In this study, we assessed TRBP protein 154 adult tumors (75 adenomas 79 carcinomas). Expression of gene a subgroup 61 tumors. Additionally, investigated metal biding sites located at the RNase IIIb domain exon 5 A strong demonstrated 32% 51% carcinomas ( p = 0.028). Similarly, overexpression more frequent (60%) than (23%, 0.006). But, among carcinomas, weak significantly metastatic non-metastatic (66% vs. 31%; 0.002). correlated reduced overall 0.004) disease-free 0.005) survival. multivariate analysis, 0.048) remained as independent predictor recurrence. Regarding gene, its did not correlate histopathological clinical parameters. No variant identified hot spot areas . conclusion, survival carcinomas.