Dyskerin and TERC expression may condition survival in lung cancer patients

Telomerase RNA component
DOI: 10.18632/oncotarget.4580 Publication Date: 2015-09-15T04:49:54Z
ABSTRACT
// Marianna Penzo 1 , Vienna Ludovini 2 Davide Treré Annamaria Siggillino Jacopo Vannucci 3 Guido Bellezza 4 Lucio Crinò Lorenzo Montanaro Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University Bologna, I-40138, Italy Medical Oncology, S. Maria della Misericordia Hospital, Perugia, I-06156, Thoracic Surgery, Institute Pathological Anatomy Histology, Correspondence to: Montanaro, e-mail: lorenzo.montanaro@unibo.it Keywords: lung cancer, dyskerin, TERC, TERC amplification, survival Received: June 19, 2015      Accepted: July 06, Published: 16, 2015 ABSTRACT Dyskerin mediates both the modification uridine on ribosomal small nuclear RNAs stabilization telomerase RNA component (TERC). In human tumors dyskerin expression was found to be associated with rRNA levels. Moreover, overexpression has been linked unfavorable prognosis in a variety tumor types, however an explanation for latter association is not available. To clarify this point, we analyzed connection between expression, levels clinical outcome two series primary cancers, differing presence gene genetic alteration inducing strong overexpression. were significantly higher bearing amplification ( P = 0.017). addition, well-established observed only without 0.003), while it present amplified 0.929). Similarly, cases 0.009) 0.584). These results indicate that influence its role maintenance high .
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