miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein

• DOI: 10.18632/oncotarget.7545
• Publication Date: 2016-02-21T10:23:23Z
• Authors: Xuchao Zhu; Dan Li; Fei Yu; Chengyou Jia; Jing Xie; Yushui Ma; Suyun Fan; Haidong Cai; Qiong Luo; Zhongwei Lv; Lihong Fan
• Keywords: Ectopic expression; FOXM1

Recent studies have implied that miRNAs may play a crucial role in tumor progression and be involved the modulation of some drug resistance cancer cells. Earlier demonstrated miR-194 was metastasis non-small cell lung (NSCLC), whereas their expression roles on NSCLC still need further elucidation. In current study, we found is decreased samples compared with adjacent non-cancerous samples, low predicts poor patient survival. Both vitro vivo experiments showed ectopic stable suppressed proliferation, migration, invasion induced apoptosis cells this suppression could reversed by reintroducing forkhead box A1 (FOXA1), functional target miR-194. addition, downregulated cisplatin-resisted human line-A549/DDP overexpression increases cisplatin sensitivity. These findings suggested inhibits proliferation reverses cisplatin-resistance useful as new potential therapeutic for NSCLC.