Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling

• DOI: 10.18632/oncotarget.7710
• Publication Date: 2016-02-25T15:22:30Z
• Authors: Peng Gao; Chunzhang Yang; Cody L. Nesvick; Michael J. Feldman; Saman Sizdahkhani; Huailei Liu; Huiying Chu; Fengxu Yang; Ling Tang; Jing Tian; Shiguang Zhao; Guohui Li; John D. Heiss; Yang Liu; Zhengping Zhuang; Guowang Xu
• Keywords: Hypotaurine

Metabolomics has shown significant potential in identifying small molecules specific to tumor phenotypes. In this study we analyzed resected tissue metabolites using capillary electrophoresis-mass spectrometry and found that hypotaurine levels strongly positively correlated with glioma grade. vitro studies were conducted show activates hypoxia signaling through the competitive inhibition of prolyl hydroxylase domain-2. This leads activation as well enhancement cell proliferation invasion. contrast, taurine, oxidation metabolite hypotaurine, decreased intracellular resulted growth arrest. Lastly, a glioblastoma xenograft mice model was supplemented taurine feed exhibited impaired growth. Taken together, these findings suggest is an aberrantly produced oncometabolite, mediating molecular pathophysiology progression. The metabolic pathway may provide potentially new target for diagnosis therapy.