Diagnostic and prognostic relevance of circulating exosomal miR-373, miR-200a, miR-200b and miR-200c in patients with epithelial ovarian cancer

• DOI: 10.18632/oncotarget.7850
• Publication Date: 2016-03-02T12:07:59Z
• Authors: Xiaodan Meng; Volkmar Müller; Karin Milde-Langosch; Fabian Trillsch; Klaus Pantel; Heidi Schwarzenbach
• Keywords: Exosome; Clinical Significance

Exosomes are membrane vesicles that mediate intercellular communication by transporting their molecular cargo from cell to cell. We investigated whether serum levels of exosomal miR-373, miR-200a, miR-200b and miR-200c circulating exosomes have diagnostic prognostic relevance in a cohort 163 epithelial ovarian cancer (EOC) patients using TaqMan MicroRNA assays ELISA. The concentrations miR-373 (p = 0.0001), miR-200a 0.0001) 0.028) were significantly higher EOC than healthy women. 0.019) could distinguish between malignant benign tumors. While the increased all FIGO/lymph node stages with FIGO stage III-IV 0.0001, p 0.008, respectively) including lymph metastasis 0.004, I-II. also associated CA125 values shorter overall survival 0.007, 0.017, respectively). excessively elevated 0.0001). In three cohorts, they positively 0.004), 0.008). conclusion, mainly observed advanced suggest these microRNAs may be involved tumor progression. high imply an excessive, active secretion EOC.