LncRNA-RMRP promotes carcinogenesis by acting as a miR-206 sponge and is used as a novel biomarker for gastric cancer

• DOI: 10.18632/oncotarget.9336
• Publication Date: 2016-05-13T04:16:12Z
• Authors: Yongfu Shao; Meng Ye; Qier Li; Weiliang Sun; Guoliang Ye; Xinjun Zhang; Yunben Yang; Bingxiu Xiao; Junming Guo
• Keywords: Male; 0303 health sciences; Gastric Juice; CA-19-9 Antigen; Carcinogenesis; Cell Cycle; Middle Aged; 3. Good health; Gene Expression Regulation, Neoplastic; Mice; MicroRNAs; 03 medical and health sciences; Cell Transformation, Neoplastic; Lymphatic Metastasis; Biomarkers, Tumor; Animals; Cyclin D2; Humans; Female; RNA, Long Noncoding; Neoplasm Transplantation; Research Paper; Aged; Cell Proliferation

Long noncoding RNAs (lncRNAs) play crucial roles in tumorigenesis. However, the mechanisms of most lncRNAs cancers are largely unknown. Because RNA component mitochondrial processing endoribonuclease (RMRP) is one dysregulated gastric cancer, this study explored its molecular carcinogenesis. RMRP levels 792 tissues, plasma and juices from patients with various stages tumorigenesis were analyzed by quantitative reverse transcription-polymerase chain reaction. Overexpression interference used to manipulate expression vector small interfering RNAs, respectively. Its evaluated flow cytometry, real-time cell analysis, plate colony formation assays, xenograft models. tissue, cancer significantly different those controls. associated Borrmann type metastasis. Plasma juice had higher sensitivity specificity than commonly markers (such as carcinoembryonic antigen carbohydrate 19-9). Knockdown inhibited proliferation vitro vivo, whereas overexpression promoted growth. Acting a miR-206 sponge, modulated cycle regulating Cyclin D2 expression. plays role occurrence can be novel biomarker for cancer.