Effects of glyprolines on free-radical oxidation in the brain neocortex of white rats in mild traumatic brain injury

• DOI: 10.18699/ssmj20220207
• Publication Date: 2022-08-29T09:20:10Z
• Authors: A. A. Kolesnikova; Yu. B. Malofey; N. Yu. Yakusheva; I. V. Tolstenok; O. V. Demidova; L. A. Andreeva; N. F. Myasoedov; M. Yu. Fleishman
• Keywords: Neocortex; Brain tissue

The aim of the study was to compare effect glyproline peptides RGRGP (Arg-Gly-Arg-Gly-Pro), RGP (Arg-GlyPro), PRPGP (Pro-Arg-Pro-Gly-Pro) and PGPL (Pro-Gly-Pro-Leu) peptide substances at various concentrations on free radical oxidation intensity brain tissues Wistar males after intraperitoneal administration solutions traumatic injury. Material methods . tissue aged 2–3 months ( n = 126) were used in experiment. RGRGP, RGP, PRPGP, provided by Academician N.F. Myasoyedov. Traumatic injury (TBI) modeled fall a load. From second fifth day experiment, animals injected intraperitoneally with peptides. On sixth day, taken out activity determined freshly prepared homogenates sections cerebral cortex chemiluminescence (CL). Results TBI significantly enhance free-radical neocortex rats, studied affect it different ways - from decrease CL (the minimum value + 0.1 group) its increase maximum RGPGP group). depends dose glyproline. Conclusions results obtained, based analysis tissues, mainly indicate degree correction homeostasis indicators. It can be assumed that Arg-Pro-Gly basis for development new drugs post-stress rehabilitation injuries levels genesis.