Transforming Growth Factor‐Beta 1 Expression in the Peri‐Implant Soft Tissues of Healthy and Failing Dental Implants

• DOI: 10.1902/jop.2003.74.4.446
• Publication Date: 2005-02-02T12:38:16Z
• Authors: Roberto Cornelini; Corrado Rubini; Massimiliano Fioroni; Gian Antonio Favero; Rita Strocchi; Adriano Piattelli
• Keywords: Peri; BETA (programming language)

Background: Transforming growth factor‐beta (TGF‐β) is composed of a family multifunctional polypeptide factors involved in embryogenesis, inflammation, regulation immune response, angiogenesis, wound healing, and extracellular matrix formation. TGF‐β1 the most common isoform found human tissues. A role TGF‐β pathogenesis periodontal disease has been suggested. The aim present study was comparative immunohistochemical evaluation normal keratinized gingiva peri‐implant soft tissues surrounding failing non‐submerged implants. Methods: Twenty patients participated this study. Ten biopsies from healthy mucosa 10 periimplant implants were obtained (one biopsy per patient). different patients. Results: In 5 cases mucosa, stromal cells positive between 1 to 5. 7 cases, epithelial layers positive, 18 cells. superficial layer negative all cases. 9 there positivity vascular component, 2 16 vessels. implants, 6 4. 15 40. component 12 30 differences expression epithelium around statistically significant ( P <0.0001). blood vessels also No difference observed groups = 0.88). Conclusion: may be one important infiltrate, production tissue repair with stimulation fibroblasts endothelial J Periodontol 2003;74:446‐450.