[Seroprevalence of anti-SARS-CoV-2 IgG/IgM antibodies in Borgosesia (Piedmont Region, Northern Italy) population: a surveillance strategy in post-lockdown period?]

• DOI: 10.19191/ep20.5-6.s2.119
• Publication Date: 2020-09-01
• Authors: Daniela Alessi; Silvio Borrè; Antonella Barale; Antonio Isabella; Fulvia Milano; Maicol Andrea Rossi; Virginia Silano; Nicola Piu; Tiziana Cena; Fabrizio Faggiano; Gruppo di Lavoro ...
• Keywords: Seroprevalence; Contact tracing; Immunoglobulin M

Background to avoid a new spread of the SARS-CoV-2 infection, post lockdown period requires implementation effective strategies for case finding and contact tracing. The presence asymptomatic subjects in population, that are responsible about 30% infections, may complicate this phase. Serological tests measurement immune response could represent an tool rapid monitoring population with infections estimating proportion territory, too. Objectives describe distribution infection Municipality Borgosesia (Piedmont Region, Northern Italy) estimate efficacy strategy identification cases. Design Cross-sectional study administration test assess seroprevalence anti-SARS-CoV-2 IgG/IgM antibodies. Setting participants all resident over age 18, where invited participate. A serological was administered enrolled detect IgG IgM antibodies on peripheral blood. Subjects or positivity were offered perform swab viral RNA research. Main outcome measures prevalence IgG, relative risks having positive symptoms similar those COVID-19 recent past has been estimated. Results 4,987 participated study, 44.5% adult Borgosesia. average 55 years. There greater participation women (54.4%), people higher education level (37.3%) without specific previous (95.1%). 245 had estimated 4.9%. 209 out who underwent RT-PCR allowed isolate 24 subjects. Conclusions values ​​estimated residing city which detection type M G blood, confirmed population-based estimates reported literature, particular results Italian survey seroprevalence. Furthermore, isolation completely subjects, have identified only through screening RNA.