[A new xanthone from hulls of Garcinia mangostana and its cytotoxic activity].

• DOI: 10.19540/j.cnki.cjcmm.20230805.201
• Publication Date: 2023-11-01
• Authors: Feng-Ning Zhao; Qi Niu; Die Xiao; Haonan Xu; Haoxin Wang; Rong-Lu Bi; Hongping He; Zhiyong Jiang
• Keywords: Xanthone; Garcinia Mangostana; HeLa; Garcinia; Sephadex; Clusiaceae

Eight compounds were isolated from ethyl acetate fraction of 80% ethanol extract the hulls Garcinia mangostana by silica gel, Sephadex LH-20 column chromatography, as well prep-HPLC methods. By HR-ESI-MS, MS, 1D and 2D NMR spectral analyses, structures eight identified 16-en mangostenone E(1), α-mangostin(2), 1,7-dihydroxy-2-(3-methy-lbut-2-enyl)-3-methoxyxanthone(3), cratoxyxanthone(4), 2,6-dimethoxy-para-benzoquinone(5), methyl orselinate(6), ficusol(7), 4-(4-carboxy-2-methoxyphenoxy)-3,5-dimethoxybenzoic acid(8). Compound 1 was a new xanthone, compound 4 xanthone dimer, 5 naphthoquinone. All this plant for first time except 2 3. Cytotoxic bioassay suggested that 1, possessed moderate cytotoxicity, suppressing HeLa cell line with IC_(50) va-lues 24.3, 35.5 17.1 μmol·L~(-1), respectively. also could suppress K562 cells an value 39.8 μmol·L~(-1).