Isolation and Identification of Antifungal Metabolites from Juncus torreyi

• DOI: 10.20307/nps.2024.30.2.161
• Publication Date: 2024-07-08T05:03:37Z
• Authors: Seong Ho Park; Ji Won Kang; Ga Hyeon Park; So-Jung Jo; Kyung-Won Min; Kyu Song Lee; Hyun Bong Park
• Keywords: Juncus; Isolation; Identification

Plants belonging to the genus Juncus are widely distributed across North America, which known make a diverse array of bioactive natural products. In 2022, torreyi, species Juncus, was firstly found in Korea. Morphological and ecological characteristics have been previously investigated; however, chemical potentials still remain be explored. present work, we focused on isolation characterization metabolites that harbor growth inhibitory activity against fungal indicator, Candida albicans. Using activity-guided discovery method, subsequently isolated purified three from most active methylene chloride-soluble fraction. Through NMR high-resolution ESI-Orbitrap-MS data analysis, were structurally determined juncatrin B (1), ensifolin I (2), juncusol (3). Metabolites 1–3 evaluated for their C. albicans revealed inhibition with an ICSUB50/SUB value 74.3, 31.5, 64.6 μg/mL, respectively.