Assessment of adherence to treatment in patients with resistant hypertension using toxicological serum analysis. A subgroup evaluation of the RESIST-POL study

• DOI: 10.20452/pamw.2648
• Publication Date: 2017-04-25T14:25:13Z
• Authors: Elżbieta Florczak; Bogdan Tokarczyk; Ewa Warchoł-Celińska; Elżbieta Szwench-...; Aleksander Prejbisz; Maria Gosk; Marek Kabat; Krzysztof Narkiewicz; Andrzej Januszewicz; Maria Kała
• Keywords: Subgroup analysis; Antihypertensive drug; Pharmacotherapy

Nonadherence to antihypertensive therapy is one of the main causes resistant hypertension.The aim our study was evaluate adherence in patients with hypertension by determining serum drug levels use liquid chromatography-tandem mass spectrometry (LC-MS/MS).The included 36 primary selected from RESIST-POL (23 men and 13 women; mean age, 52.5 ±9.1 years; range, 22-67 number drugs, 5.3 ±1.4), who met all 3 inclusion criteria: ≥4 drugs; average daytime ambulatory systolic blood pressure ≥140 mmHg; clinical features suggesting nonadherence. All had their assessed using LC-MS/MS. Patients whom level at least 1 below limit quantification for method used were regarded as nonadherent.Of patients, nonadherence observed 31 (86.1%), none prescribed drugs detected (complete nonadherence) 5 (13.9%). In 26 (72.2%), could not be (partial nonadherence).In study, we documented a surprisingly low treatment hypertension. Our results suggest that, particularly those analysis LC-MS/MS might allow avoid comprehensive costly diagnostic work-up including biochemical imaging studies.