Studi In Silico Senyawa Hylocereus polyrhizus dan Allium sativum terhadap Enzim HMG-CoA Reduktase

• DOI: 10.20527/jps.v8i2.11639
• Publication Date: 2022-02-07T04:58:37Z
• Authors: Normaidah Normaidah; Dian Nurmansyah
• Keywords: 0106 biological sciences; 01 natural sciences

Ekstrak buah naga merah (Hylocereus polyrhizus) dan ekstrak bawang putih (Allium sativum) diketahui mampu menurunkan kadar kolesterol total darah dalam studi in vivo. Penambatan molekul dapat dilakukan memprediksi senyawa yang bertanggung jawab berdasarkan nilai docking. Tujuan dari penelitian ini adalah mengetahui zat aktif potensial H. polyrhizus A. sativum berperan penting penurunan melalui jalur inhibisi enzim HMG-CoA reduktase uji silico. Reseptor digunakan (PDB ID: 1HW9) dengan ligan natif simvastatin dipreparasi menggunakan YASARA. Struktur sebanyak 19 17 digambar MarvinSketch pada pH 7,4 10 bentuk konformasi. Proses penambatan program PLANTS divisualisasi Discovery Studio Visualizer. Ligan menunjukkan RMSD sebesar 1,5265 Å docking -79,1320. Senyawa 4, serta 36 kedekatan relative lebih 95%. diprediksi penghambatan secara molekul. Kata Kunci: Buah Naga Merah, Bawang Putih, Vitamin E, Antilipidemia, Kolesterol Total The red dragon fruit extract and garlic are able to decrease the blood cholesterol levels vivo study. molecular can predict responsible compound based on value. purpose of this study is determine potential active substances which play an important role reducing through reductase enzyme inhibition pathway silico receptor was with native ligand prepared using structure (19 compounds from compouns were drawn at 7.4 conformations. process carried out visualized showed value 1.5265 a -79.1320. 4 closeness ligands more than 95% score. Based docking, these be by inhibiting enzyme.