Commentary on: Combination of Metabolic Intervention and T Cell Therapy Enhances Solid Tumor Immunotherapy

• DOI: 10.20900/immunometab20210016
• Publication Date: 2021-04-01T05:55:31Z
• Authors: Anthos Christofides; Natalia M. Tijaro...; Vassiliki A. Bous...
• Keywords: Cancer Immunotherapy; Reprogramming; Cell metabolism; Cell therapy

Abstract Metabolism is a common cellular feature. Cancer creates suppressive microenvironment resulting in inactivation of antigen-specific T cells by metabolic reprogramming. Development approaches that enhance and sustain physiologic properties cell metabolism to prevent promote effector function the tumor an urgent need for improvement cell-based cancer immunotherapies.