Vascular Metabolism as Driver of Atherosclerosis: Linking Endothelial Metabolism to Inflammation

• DOI: 10.20900/immunometab20210020
• Publication Date: 2021-05-18T01:05:31Z
• Authors: Kim E. Dzobo; Katie M. L. Hanford; Jeffrey Kroon
• Keywords: Vascular permeability; Extravasation

The endothelium is a crucial regulator of vascular homeostasis by controlling barrier integrity as well acting an important signal transducer, thereby illustrating that endothelial cells are not inert cells. In the context atherosclerosis, this function impaired and become activated, resulting in upregulation adhesion molecules, secretion cytokines chemokines internalization integrins. Finally, leads to increased vessel permeability, facilitating leukocyte extravasation fostering pro-inflammatory environment. Additionally, activated can form migrating tip proliferative stalk cells, formation new blood vessels. Emerging evidence has accumulated indicating cellular metabolism fueling these pro-atherosclerotic processes, including neovascularization inflammation, contributing plaque progression altering stability. Therefore, further research necessary unravel complex mechanisms underlying cell metabolic changes, exploit knowledge for finding developing potential future therapeutic strategies. review we discuss alterations undergo inflammation atherosclerosis how relates changes functioning. will describe several targets currently being used interventions.