Does Altered Cellular Metabolism Underpin the Normal Changes to the Maternal Immune System during Pregnancy?

• DOI: 10.20900/immunometab20210031
• Publication Date: 2021-10-07T01:31:13Z
• Authors: Benjamin J. Jenkins; April Rees; Nicholas Jones; Catherine A. Thor...
• Keywords: Catabolism; Homeostasis

Pregnancy is characterised by metabolic changes that occur to support the growth and development of fetus over course gestation. These can be classified into two distinct phases: an initial anabolic phase prepare adequate store substrates energy which are then broken down used during a catabolic meet energetic demands mother, placenta fetus. Dynamic readjustment immune homeostasis also feature pregnancy likely linked in substrate utilisation at this time. As cellular metabolism increasingly recognised as key determinant cell phenotype function, we consider how maternal might contribute T plasticity pregnancy.