Membrane Active Peptides and Their Biophysical Characterization

• DOI: 10.20944/preprints201807.0008.v1
• Publication Date: 2018-07-05T05:35:09Z
• Authors: Fatma Gizem Avci; Berna Sariyar Akb...; Elif Ozkirimli
• Keywords: Cell membrane

In the last 20 years, an increasing number of studies have been reported on membrane active peptides, which exert their biological activity by interacting with cell either to disrupt it and lead lysis or translocate through deliver cargos into reach target. These peptides are attractive alternatives currently used pharmaceuticals. Antimicrobial (AMPs) designed for drug gene delivery in pipeline suggest that these will soon constitute a significant percentage market. Here, we focus two most prominent classes peptides; AMPs cell-penetrating (CPPs). group integrity inhibit cellular functions bacteria, virus fungi. CPPs another mainly function as cargo-carriers even though they may also show antimicrobial some extent. Biophysical techniques understand how interact shed light peptide–membrane interaction at various levels detail. Structural investigation presence provides important clues effect environment peptide conformations. Advances live imaging allowed examination action single molecule level. addition experimental biophysical techniques, molecular dynamics simulations provided peptide-lipid interactions entry process atomic this review, summarize recent advances computational particular emphasis amphipathic AMP melittin CPP pVEC.