Synergistic Hepatoprotective Interaction between α-Tocopherol and Ascorbic Acid on Paracetamol Induced Liver Damage in Rats

• DOI: 10.20944/preprints202006.0122.v1
• Publication Date: 2020-06-10T09:38:56Z
• Authors: Saidul Islam Khan; Mahmuda Begum; Rama Chowdhury; Md. Mizanur Rahman; Muhammad Asaduzzaman
• Keywords: Acetaminophen; Malondialdehyde; alpha-Tocopherol

Background and objectives: The hepatoprotective activity of vitamin E C is evident due to their ability modulating the antioxidant pathway. In this study, we have evaluated effects α-tocopherol ascorbic acid on paracetamol induced liver damage with offsetting various levels drug treatment following an in vivo experimental protocol Wistar albino male rats. Materials Methods: level lipid peroxidation as well histological examination tissues were observed among 50 rats evaluate effect hepatocytes. experiment was divided into 5 groups (10 each group)- Basal control group (Group-I, propylene glycol), Paracetamol treated (Group –II), pretreated & –III), Ascorbic –IV) –IV). Results: mean (± SD) Malondialdehyde (MDA) concentration significantly reduced (P<0.001), (P≤0.05) combined (P<0.001). Statistically significant differences findings rat serum alanine aminotransferase (ALT) also higher plus Conclusion: pretreatment better than or alone against damage. decrement free radicals produced by could be a toxicity.