The Controversial Roles of Resveratrol in Mammalian Reproduction

• DOI: 10.20944/preprints202009.0003.v1
• Publication Date: 2020-09-02T03:57:52Z
• Authors: Rolando Pasquariello; Nicole Verdile; Tiziana A.L. Brevini; Fulvio Gandolfi; Cristiano Boiti; Massimo Zerani; Margherita Maranesi
• Keywords: Sperm Quality

Resveratrol is one of the most investigated natural polyphenolic compounds and contained in more than 70 types plants red wine. The widespread interest this polyphenol derives from its antioxidant, anti-inflammatory anti-aging properties. Several studies have established that resveratrol regulates animal reproduction. However, mechanisms action potential therapeutic effects are still unclear. This review aims to clarify role male female reproductive functions, with a focus on animals veterinary interest. In female, has been considered phytoestrogen due capacity modulate ovarian function steroidogenesis via sirtuins, SIRT1, particular. also used enhance aged oocyte quality, as gametes cryo-protectant mainly anti-apoptotic effects. male, enhanced testes spermatogenesis through activation AMPK pathway. Furthermore, supplemented semen extenders improving preservation sperm quality. conclusion, potentially beneficial for ameliorating function. unclear data, further necessary consolidate these findings.