Sex Differences in Photoprotective Responses to 1,25- Dihydroxyvitamin D3 in Mice are Modulated by the Estrogen Receptor-β

• DOI: 10.20944/preprints202012.0398.v1
• Publication Date: 2020-12-16T08:53:05Z
• Authors: Wannit Tongkao-on; Chen Yang; Bianca Y McCarthy; Warusavithana GM ...; Mark S Rybchyn; Clare Gordon-Thomson; Katie M Dixon; Gary M Halliday; Vivienne E Reeve; Rebecca S. Mason
• Keywords: Pyrimidine dimer; Immunosuppression

Susceptibility to photoimmune suppression and photocarcinogenesis is greater in male than female humans mice exacerbated estrogen receptor-beta knockout (ER-β-/-) mice. We previously reported that the active vitamin D hormone, 1,25-dihydroxyvitamin D3 (1,25(OH)2D) applied topically protects against ultraviolet radiation (UV)-induction of cutaneous cyclobutane pyrimidine dimers (CPDs) contact hypersensitivity (CHS) Here we compare these responses versus Skh:hr1 mice, ER-β-/- wild type C57BL/6 ER-blockaded Induction CPDs was significantly more effectively reduced by 1,25(OH)2D or respectively. This correlated with sunburn inflammation but not Furthermore, although alone dose-dependently suppressed basal CHS UV-induced immunosuppression universally observed. In decreased dose-dependently, Skh:hr1, These results reveal a sex bias genetic, inflammatory immune photoprotection favoring dependent on presence ER-β.