A Novel Piezoelectric Ultrasonic Biological Micro-Dissection Device Based on Flexure Mechanism for Suppressing Vibration

• DOI: 10.20944/preprints202012.0520.v1
• Publication Date: 2020-12-21T11:15:02Z
• Authors: Haibo Huang; Yifan Pan; Yan Pang; Hao Shen; Xiwei Gao; Yichen Zhu; Liguo Chen; Lining Sun
• Keywords: 0303 health sciences; 03 medical and health sciences; automotive_engineering

Biological micro-dissection has a wide range of applications in the field molecular pathology. The current laser-assisted dissection technology is expensive, and laser radiation can lead to sample contamination. As an economical pollution-free method, piezoelectric ultrasonic application prospect. However, performance unsatisfactory. In this paper, novel device based on flexure mechanism proposed order solve problems low dissecting precision excessive wear needle caused by harmful lateral vibration device. By analyzing flexibility hinge, type beam optimal design parameters are determined. Through comparing harmonic response simulation analysis traditional without mechanism, newly designed achieves best effect when driving frequency 28kHz, compared with device, suppression improved 68%. Then, 3D printing technology, prototype was produced, its tested. It found that did indeed suppress tip. Finally, experiments 5μm thick paraffin-embedded rat liver sections were carried out, effects different analyzed, obtained. tissue condition tip between under their parameters, it proved not only significantly improves effect, but also service life durability needle, which beneficial reduce equipment costs.