The Advance Cancer Immunotherapy Techniques and the Future Perspective of Modified T Cell Therapy

• DOI: 10.20944/preprints202105.0142.v1
• Publication Date: 2021-05-11T08:22:03Z
• Authors: Md. Al Saber; Partha Biswas; Dipta Dey; Md. Abu Kaium; Md. Aminul Islam; Miss Ismoth Ara T...; MD. Hasanur Rahman; Tanjim Ishraq Rah...; Md. Yeaman Biswas; Priyanka Paul; Md. Ataur Rahman; Md. Nazmul Hasan; Bonglee Kim
• Keywords: Cancer Immunotherapy; Cell therapy; Adoptive Cell Transfer; Immune checkpoint

The mechanisms involved in immune responses to cancer have been extensively studied for several decades and, considerable attention has paid harnessing the system's therapeutic potential. Cancer immunotherapy established itself as a promising new treatment option variety of types. Various strategies including vaccines, monoclonal antibodies (mAbs), adoptive T-cell-cancer therapy and test gained prominence through immunotherapy. However, it remains be accomplished full potential In spite having startling aspects, immunotherapies some difficulties inability effectively targeting antigens abnormalities patient response. With advancement technology, this system changed genome-based process human body generation engineered T cells. Due its high specificity, CRISPR-Cas9 become simple flexible genome-editing tool target nearly any genomic locus. Recently, CD19-mediated CAR-T cell (chimeric antigen receptor cell) opened avenue cancer, though low efficiency is major drawback process. Thus, increasing (engineered cells that induce chimeric receptor) by using technology could better weapon fight against cancer. review, we broadly focused on use modification T-cell, which can specifically recognize used therapeutics We also demonstrated other