In vivo Neuropharmacological Potential of <em>Gomphandra tetrandra</em> (Wall.) Sleumer and in-silico Study against β-Amyloid Precursor Protein

• DOI: 10.20944/preprints202107.0564.v1
• Publication Date: 2021-07-27T07:36:17Z
• Authors: Md Saidur Rahman; Md Nazmul Hasan Z...; Md. Aminul Islam; Md Munaib Hasan; Md. Muzahidul Islam; Farzana Yasmin; Partha Biswas; Akinori Hirashima; Md. Ataur Rahman; Md. Nazmul Hasan; Bonglee Kim
• Keywords: Docking (animal)

Medicinal plants possess a surplus of novel and biologically active secondary metabolites that are responsible for counteracting diseases. Traditionally, Gomphandra tetrandra (Wall.) Sleumer is used to treat mental disorders. The present research was designed explore phytochemicals from the ethanol leaf extract identify potential pharmacophore(s) in treatment neurological chemical compounds experimental plant were identified through GC-MS analysis. Besides, in-vitro antioxidant activity assessed using different methods. Furthermore, in-vivo Swiss-albino mice. Computer aided analysis appraised determine best-fit phytoconstituent total fifteen against beta-amyloid precursor protein. revealed highest content 9, 12, 15-octadecatrienoic acid (Z, Z, Z). Also, showed potent anti-oxidant assays. assays, disclosed significant (p&amp;lt;0.05) activity. most favorable as agents selected via ADMET profiling molecular docking studied with Moreover, computer study, 1, 5-Diphenyl-2H-1, 2, 4-triazoline-3-thione (Pub Chem CID: 2802516) more than other strong binding affinity vivo silico studies neuropharmacological features G. leaves natural agent disorders, especially Alzheimer&amp;rsquo;s disease.