The Influence of Overexpressed Fibroblast Growth Factor Receptors Towards Vitamin D Receptor Expression and Activity

• DOI: 10.20944/preprints202110.0304.v1
• Publication Date: 2021-10-28T09:14:11Z
• Authors: Aleksandra Marchw...; Agnieszka Jakuszak; Anna Grembowska; Parmila Kumari; Ewa Marcinkowska
• Keywords: 0301 basic medicine; 03 medical and health sciences; oncology_oncogenics; 3. Good health

(1) Background: Many malignancies are driven by mutations which affect the gene for fibroblast growth factor receptor (FGFR) 1. Previously we have documented that signal transduction from FOP2–FGFR1 fusion protein in KG1 cells downregulated expression of vitamin D (VDR) gene. In this paper investigated if also other FGFRs were responsible regulation VDR expression. (2) Methods: We used human myeloid leukemia U937, and bone cancer cell line U2OS, transfection methods order to address above questions. (3) Results: overexpression FGFR 1-4 caused shift granulocytic differentiation, upregulated VDR, sensitized these 1,25-dihydroxyvitamin (1,25D)-induced monocytic while cells, activated FGF1 was not activity. (4) Conclusions: Since occurs many neoplasms, it may be reasonable use 1,25D analogs cancers, leads upregulation.