Microbial Pattern and Antibiotic Resistance of Severe Pneumonia in A National Referral Hospital in Indonesia

• DOI: 10.20944/preprints202203.0072.v1
• Publication Date: 2022-03-04T11:55:18Z
• Authors: Gurmeet Singh; Nova Bornida Fauzi; Sudirman Fakhrudd...; Dita Aditianingsih; Adhrie Sugiarto; Tonny Loho; Dewi Wulandari
• Keywords: Amikacin; Sulbactam; Acinetobacter baumannii; Hospital-acquired pneumonia; Cefoperazone

Background: Patients hospitalized in the intensive care unit (ICU) have a higher susceptibility to infections. Respiratory infections are most common nosocomial Rising antibiotic resistance due indiscriminate use of antibiotics and poor adherence standard precaution healthcare facilities compounds problem. The main aim this study is assess microbial patterns from bronchoalveolar lavage specimens severe pneumonia patients. Methods: This retrospective was conducted an Indonesian tertiary hospital January 2016-December 2020. Written verbal informed consent obtained prior bronchoscopy procedures. were enrolled if they had community-acquired (CAP) according American Thoracic Society (ATS)/Infectious Disease America (IDSA) criteria, high-risk hospital-acquired (HAP), late-onset ventilator-associated (VAP), or caused by Coronavirus disease (COVID-19). via inoculated on general semi-sloid thioglycolate media. Testing for done using disk diffusion method. Results: Two hundred one patients’ data analyzed. majority patients males (65,17%) above 60 years age. type CAP (39,3%). Neurologic/cerebrovascular comorbidity (35,32%). Acinetobacter baumannii frequently isolated microorganism. Ampicillin/sulbactam amikacin found yield lower resistance. Conclusion: Combination ampicillin/sulbactam appeared effective as initial empirical therapy Further studies needed evaluate feasibility effectiveness combined therapy.