ZIKA Virus Envelope Protein Forms Disulfide Bond-Dependent Polymers: Evidence for A Redox Imbalance during Infection

• DOI: 10.20944/preprints202204.0030.v1
• Publication Date: 2022-04-06T08:13:55Z
• Authors: Grégorie Lebeau; Jonathan Turpin; Etienne Frumence; Daed El Safadi; Wissal harrabi; Philippe Desprès; Pascale Krejbich-...; wildriss viranaïcken
• Keywords: Zika Virus; Flavivirus

Flaviviruses replicate in membrane factories associated with the endoplasmic reticulum (ER). Significant levels of flavivirus viral protein accumulation contribute to ER stress. As a consequence, host cell exhibits an Unfolded Protein Response (UPR), subsequently stimulating appropriate cellular responses such as adaptation, autophagy or apoptosis. The correct redox conditions this compartment are essential form native disulfide bonds proteins. ZIKA virus (ZIKV) has ability induce persistent stress leading activation UPR pathways. In study, we wondered whether ZIKV affects balance and consequently oxidative folding ER. We found that replication influences state aggregation envelope amyloid-like structures infected cells.