SARS-CoV-2 Detection in Fecal Samples in Sym-asymptotic Patients with Typical Findings of COVID-19 on Ag-RDT and SARS-CoV-2 RT-PCR Tests

• DOI: 10.20944/preprints202209.0439.v1
• Publication Date: 2022-09-29T06:07:13Z
• Authors: Richard Odongo Ma...; Benson Onyango; Alfred Ochieng; Shehu Shagare Awandu; Pamela Were; Joy Nyangasi Kirungu; Marceline Adhiamb...; Erick Muok; Stephen Munga; Fredrick Ogutu; Angeline Orwa; Fredrick Okumu; Clayton Onyango; Dorothy Awuor; Francis Orata; Justine Ochieng’-...; Bonface Oure; Regina Nyunja; Fredrick Ade; Sharley Indechi; Erick Okuto; Benson Estambale
• Keywords: Coronavirus; Pandemic

Coronavirus is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which emerged as global pandemic in 2019 from Wuhan, China. Since its emergence, it has immense suffering to human life, 6.27 million lives have been lost, movement curtailed and social dynamics disrupted. The golden standard for getting samples SARS-CoV-2 detection through oral- nasopharyngeal swab, this method of sample collection invasive uncomfortable, thus stigmatized the general population, thereby impeded progress controlling spread mass testing. Being contact disease, mechanisms encourage testing key reduce spread. This study developed complimentary type test SARS-CoV-2, use feces. Fecal were collected 100 asym-symptomatic individuals suspected be infected with COVID-19, virus RNA was then extracted profiled Real Time Polymerase Chain Reaction (RT-qPCR). antigen rapid diagnostic revealed high positivity rate 44%, but real time polymerase chain reaction results on fecal significant variation, number patients tested positive stool compared swabs, 43 37%, respectively. detected both symptomatic asymptomatic individuals; however, registered higher 25% 20% among patients. Vaccination only lowered risk infection, fully partially vaccinated infection level 10% unvaccinated. Finally, gender parity relation COVID19 evaluated, more females (56%) males recruited study, out (20; 43.4%) positive, 26 (56.6%) negative based RT-qPCR outcomes. Based outcome (Ag-RDT) however cheap or fast does not provide accurate information, moreover, stay longer within Oro-nasopharyngeal region, invalid results, feces should adopted confirmatory ascertain status an individual.