Is there a Role of Warburg Effect in Prostate Cancer Aggressiveness? Analysis of Expression of Enzymes of Lipidic Metabolism by Immunohistochemistry in Prostate Cancer Patients (DIAMOND Study)

• DOI: 10.20944/preprints202212.0068.v1
• Publication Date: 2022-12-05T09:03:16Z
• Authors: Giorgio Ivan Russo; Maria Giovanna As...; Arturo Lo Giudice; Giuseppe Trefiletti; Sebastiano Cimino; Matteo Ferro; Riccardo Lombardo; Cosimo De Nunzio; Giuseppe Morgia; Eliana Piombino; Maria Failla; Rosario Caltabiano; Giuseppe Broggi
• Keywords: life_sciences_other; 0301 basic medicine; lipidic; warburg effect; lipidic; metabolism; mortality; prognosis; prostate cancer; radical prostatectomy; prostate cancer; mortality; radical prostatectomy; Article; 3. Good health; lipidic; metabolism; mortality; prognosis; prostate cancer; radical prostatectomy; Warburg effect; 03 medical and health sciences; 0302 clinical medicine; Warburg effect; prognosis; metabolism

Prostate Cancer (PCa) is still ranked as the first cancer in male population and evidences have suggested an alteration of glycemic and lipidic metabolism that are related to its progression and prognosis. Aim of the study is to investigate associations between enzymes’ expression, especially involved in the lipidic pathway, and PCa aggressiveness. We retrospectively analyzed data from 390 patients with PCa or benign prostatic hyperplasia (BPH) at the Department of Urology, University of Catania. Immunohistochemical slides were evaluated for the expression of proteins related to glucose and lipidic metabolism. A total of 286 were affected by PCa while 104 by BPH. We demonstrated that ATP-lyase (odds ratio [OR]: 1.71; p<0.01), fatty acide sinthase (OR: 4.82; p<0.01), carnitine palmitoyl transferase-1a (OR: 2.27; p<0.05) were associated with androgen receptor (AR) expression. We found that steaoryl Co-A desaturase expression in PCa patients with total cholesterol ≥ 200 mg/dl was independently associated with ISUP ≥4 (OR: 4.22; p=0.049). We found that CPT-1a+ was associated with biochemical recurrence (hazard ratio: 1.94; p=0.03]). Our results support the evidences that the manipulation of lipidic metabolism could serve in the future to contrast PCa progression.