Exotoxins from <em>Clostridium septicum</em> Kill Mouse Peritoneal Macrophages: A Possible Mechanism of Bacterial Immune-Evasion at Infection Sites

• DOI: 10.20944/preprints202304.0270.v1
• Publication Date: 2023-04-13T00:45:46Z
• Authors: Rodolfo Matias Or...; Claudia Cáceres; Teresa Ines Cortiñas; Sandra Gomez Mejiba; Corina Verónica S...; María Aida Mattar...
• Keywords: Clostridium septicum

The induction of macrophage death is regarded as a potential mechanism by which components secreted Clostridium septicum are used to evade the innate immune response and cause tissue damage. This study aimed determine effect partially purified fractions extracellular proteins C. on mouse peritoneal macrophages. Elicited macrophages were incubated with into culture medium. After incubation, we found that protein fraction molecular weight &amp;ge; 100 kDa caused significant cell in macrophages, changed morphology, increased markers apoptosis autophagy, expression (protein mRNA) IL-1 TNF&amp;alpha;. Our data suggest (MW &amp;ge;100kDa) induce promoting autophagy-triggered apoptosis. may contribute our understanding evasion at infection site.