Polymorphisms of the GCLC Gene Are Novel Genetic Markers For Susceptibility To Psoriasis Associated With Alcohol Abuse And Cigarette Smoking

• DOI: 10.20944/preprints202305.0461.v1
• Publication Date: 2023-05-09T00:35:46Z
• Authors: Ekaterina Efanova; Olga Bushueva; Roman Saranyuk; Anna Surovtseva; Mikhail Churnosov; Maria Solodilova; Alexey Polonikov
• Keywords: SNP

The aim of this pilot study was to investigate whether single nucleotide polymorphisms (SNP) in the gene encoding catalytic subunit glutamate cysteine ligase (GCLC) are associated with risk and clinical features psoriasis. A total 944 unrelated individuals, including 474 patients a diagnosis psoriasis 470 healthy controls, were recruited for study. Six common SNPs GCLC genotyped using MassArray-4 system. Polymorphisms rs648595 (OR=0.56 95%CI 0.35-0.90, Pperm=0.017) rs2397147 (OR=0.54 0.30-0.98, Pperm=0.05) susceptibility males. In male group, diplotype rs2397147-C/C×rs17883901-G/G decreased (FDR-adjusted P=0.014), whereas rs6933870-G/G×rs17883901-G/G P=0.045) showed association increased disease females. Joint effects tobacco smoking (rs648595 rs17883901) alcohol abuse rs542914) on observed (Pperm≤0.05). Furthermore, we found multiple sex-independent associations between various such as earlier onset, psoriatic triad, specific localizations skin lesions. present is first show that significantly related its features.