Trodusquemine (MSI-1436) restores metabolic flexibility and mitochondrial dynamics in insulin-resistant equine hepatic progenitor cells (HPCs)

• DOI: 10.20944/preprints202307.0324.v1
• Publication Date: 2023-07-06T05:35:35Z
• Authors: Badr Qasem; Lynda Bourebaba; Agnieszka Dąbrowska; Jarosław Królicze...; Jacek Łyczko; Krzysztof Marycz
• Keywords: MFN2

Equine metabolic syndrome (EMS) is a major health threat in veterinary endocrinology medicine worldwide, and there growing interest utilizing molecular agents for modulation of hepatocyte function potential clinical applications with recent studies showing promising results the inhibition PTP1B on adipose-derived stromal cells. In this study, we investigated effects MSI-1436 equine hepatic progenitor cells (HPCs) terms their proliferative activity, glucose uptake, mitochondrial morphogenesis under lipotoxic condition. Our study found that promotes entry HPCs cell cycle rescues them from palmitate-induced apoptosis by regulating dynamics biogenesis. also increases uptake protects stress reorganizing morphological architecture Additionally, our findings suggest enhances 2-NBDG internalization increasing expression SIRT1, which associated liver insulin sensitivity, modulating number morphotype through PINK1, MFN1, MFN2 increased expression. provides evidence has positive impact cells, indicating its therapeutic value treatment EMS dysregulation.