Dysregulated Signalling Pathways Driving Anti-cancer Drug Resistance

• DOI: 10.20944/preprints202307.1284.v1
• Publication Date: 2023-07-21T00:10:32Z
• Authors: Nauf Bou Antoun; Athina-Myrto Chioni
• Keywords: Male; Phosphatidylinositol 3-Kinases; Drug Resistance; Tumor Microenvironment; Humans; Female; Antineoplastic Agents; Review; Neoplasm Recurrence, Local; 3. Good health; Signal Transduction

One of the leading causes death worldwide, in both man and woman, is cancer. Despite significant development therapeutic strategies, inevitable emergence drug resistance limits success impedes curative outcome. Intrinsic acquired are common mechanisms responsible for cancer relapse. Several factors crucially regulate tumourigenesis resistance, including physical barriers, tumour microenvironment (TME), heterogeneity, genetic epigenetic alterations, immune system, burden, growth kinetics undruggable targets. Moreover, transforming factor-beta (TGF-β), Notch, epidermal factor receptor (EGFR), integrin-extracellular matrix (ECM), nuclear kappa-light-chain-enhancer activated B cells (NF-κB), phosphoinositol-3-kinase/protein kinase B/mammalian target rapamycin (PI3K/Akt/mTOR), wingless-related integration site (Wnt)/β-catenin), Janus kinase/signal transducers activators transcription (JAK/STAT) RAS/RAF/mitogen-activated protein (MAPK) signalling pathways some key players that have a pivotal role mechanisms. To guide future treatments improve results, deeper comprehension necessary. This review will cover intrinsic give comprehensive overview recent research on enable to bypass barriers put by treatments, like “satellite navigation”, find alternative routes carry their “journey” progression.